20
Jun 2015
Next-Generation GigaHertz NMR
1 GHz NMR system with a first-generation, unshielded 23.5 Tesla magnet has been running at the Ultra-High Field NMR Center in Lyon, France since 2009. Bruker intends to deliver the world’s first, next-generation 1GHz NMR systems with actively-shielded Aeon™ 1 GHz magnets to the University of Bayreuth, Germany, in late 2015, and to the University of Toronto, Canada in the first half of 2016.
Ultra-high field NMR in combination with other experimental and computational methods, has recently been shown to enable more detailed studies of the structural ensembles, post-translational modifications, dynamics, multiple interactions, specific binding partners, signaling and regulatory roles, formation of membrane-less cellular organelles, and other functions of Intrinsically Disordered Proteins (IDPs).
A. Grevtsev |
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14
Jun 2015
From what we have already seen
At CMR we have measured NMR spectra of these nuclei
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04
Jun 2015
May
Total in May 1457 service applications were carried out.
All together measured:
- 1372 1H spectra
- 310 13C spectra
- 142 DEPT spectra
- 6 COSY spectra
- 14 NOESY spectra
- 34 31P spectra
- 82 19F spectra
196 applications were carried out which jointly took 1831 hours of measurements.
A. Grevtsev |
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03
Jun 2015
Excursion for participants of the conference
Today, participants of the conference “Development of centers for collective use of scientific equipment and unique research units” have visited our center. During the demonstration our guests have learned how we organize the work, how to start a joint research project and which results were achieved in 2014.
A. Grevtsev |
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01
Jun 2015
Summer practice for high-school students
Artem Grevtsev and Anton Mazur have presented two educational research projects which high-school students of leading physical and mathematical schools of St. Petersburg could run during their summer practice in June.
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28
May 2015
Solvent for extra low-temperature NMR
For the first time at CMR Dr. Benjamin Koeppe has synthsized a mixture of deuterated freon gases (CDF3/CDF2Cl). Liquefied freons may serve as a solvent for extra low-temperature NMR experiments in liquid state (down to 100 K).
References:
1. B. Koeppe, J. Guo, P.M. Tolstoy, G.S. Denisov, H.-H. Limbach, “Solvent and H/D Isotope Effects on the Proton Transfer Pathways in Heteroconjugated Hydrogen-Bonded Phenol-Carboxylic Acid Anions Observed by Combined UV–vis and NMR Spectroscopy”, J. Am. Chem. Soc. 2013, 135, 7553-7566. DOI: 10.1021/ja400611x.
2. J. Guo, P.M. Tolstoy, B. Koeppe, N.S. Golubev, G.S. Denisov, S.N. Smirnov, H.-H. Limbach, “Hydrogen Bond Geometries and Proton Tautomerism of Homo-Conjugated Anions of Carboxylic Acids Studied via H/D Isotope Effects on 13C NMR Chemical Shifts”, J. Phys. Chem. A 2012, 116, 11180-11188. DOI: 10.1021/jp304943h.
3. D. Ajami, P.M. Tolstoy, H. Dube, S. Odermatt, B. Koeppe, J. Guo, H.-H. Limbach, J. Rebek Jr., “Compressed Hydrogen Bonds Isolated in Encapsulation Complexes”, Angew. Chem. Int. Ed. 2011, 50, 528-531. DOI: 10.1002/anie.201002182.
4. P.M. Tolstoy, P. Schah-Mohammedi, S.N. Smirnov, N.S. Golubev, G.S. Denisov, H.-H. Limbach, „Characterization of Fluxional Hydrogen-Bonded Complexes of Acetic Acid and Acetate by NMR: Geometries and Isotope and Solvent Effects”, J. Am. Chem. Soc., 2004, 126, 5621-5634. DOI: 10.1021/ja039280j.
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21
May 2015
A. Rozentsvet has presented a lecture
On 21.05 at CMR Dr. Victor A. Rozentsvet (Institute of Ecology of the Volga River Basin, Russian Academy of Sciences, Togliatti, Russia) has presented a lecture titled “Unusual NMR spectra of branched diene polymers. Questions without answers.”
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19
May 2015
Combined acquisition of NMR and UV-vis absorption spectra
Dr. Benjamin Koeppe (Humboldt-Universität zu Berlin, Germany), who previously worked in the group of Prof. Dr. Hans-Heinrich Limbach and developed a technique for the combined acquisition of NMR and UV-vis absorption spectra (UVNMR), is installing and demonstrating the equipment at the CMR. The figure shows NMR and UV-vis spectra of 2-chloro-4-nitrophenol dissolved in chloroform, obtained simultaneously within the magnet of an NMR spectrometer..
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14
May 2015
Dr. Benjamin’s Koeppe presentation
On Monday 18.05.15 at 15:00 in the room 1093 (seminar room of X-ray diffraction center) our guest Dr. Benjamin Koeppe (HU Berlin, Germany) will give a presentation titled “Combined NMR and UV-vis studies of hydrogen bonded complexes”.
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