Total in June 1074 service applications were carried out.
All together measured:
60 applications were carried out which jointly took 1070 hours of measurements.
A delegation of the Hannover Medical School (Medizinische Hochschule Hannover) has visited our Center today:
A group of bachelor students from the Faculty of Chemistry visited our Center today.
V.A. Rassadin, E. Nicolas, Y. Six
“Ti(OiPr)4/nBuLi: an attractive reagent system for [2+2+2] cyclotrimerisation reactions”
Chem. Commun. 2014, Advance Article
DOI: 10.1039/C4CC02698E
A convenient method for the [2+2+2] cyclotrimerisation of alkynes using Ti(OiPr)4/nBuLi is presented. Homotrimerisation of arylacetylenes proceeds within minutes with excellent regioselectivity. Moreover, the intermolecular construction of ABB heterotrimers can be achieved selectively from two different alkynes with similar electronic properties. The method is also suitable for the synthesis of pyridines.
V.V. Sokolov, A.Yu. Ivanov, M.S. Avdontseva, A.A. Zolotarev
“Stereochemistry and NMR Spectra of Some Tricyclic Condensed Thiazolidine Derivatives with a Bridgehead Nitrogen Atom”
Chem. Hetercycl. Compd. 2014, 50, 550-556
DOI: 10.1007/s10593-014-1506-3
The configuration of a series of tricyclic condensed thiazolidines with a bridgehead nitrogen atom, for which erroneous data had been published, was determined by X-ray structural analysis and NMR spectroscopy.
The second part of the G-RISC workshop “NMR as interdisciplinary tool for the study of non-covalent interactions” took place on 16 and 18 June.
The program was as follows:
J. Malinina, T.Q. Tran, A.V. Stepakov, V.V. Gurzhiy, G.L. Starova, R.R. Kostikov, A.P. Molchanov
“[3+2] Cycloaddition reactions of arylallenes with C-(N-arylcarbamoyl)- and C,C-bis(methoxycarbonyl)nitrones and subsequent rearrangements”
Tetrahedron Lett. 2014, 55, 3663-3666
DOI: 10.1016/j.tetlet.2014.04.107
The first example of 1,3-dipolar cycloaddition reactions of nitrones with arylallenes is described. C-Carbamoylnitrones react with the C1single bondC2 double bond of arylallenes affording the corresponding 4-methyleneisoxazolidines in good yields. N-Aryl-C,C-bis(methoxycarbonyl)nitrones usually gave rearranged products: mixtures of 4,5-dihydro-4-oxo-1H-benzo[b]azepine-2,2(3H)dicarboxylates and 4-oxo-1,5-diarylpyrrolidine-2,2-dicarboxylates.
St. Petersburg Branch of the Russian Chemical Society invites to a lecture of Prof. Dr. Hans-Heinrich Limbach from Dahlem Research School of Molecular Sciences of the Freie Universität Berlin, Germany
The lecture will take place in Mendeleev’s center of the St. Petersburg State University (Universitetskaya nab. 7/9) on the 17 of June 2014 at 15:00. Additional info: 323-41-20.
P. R. Golubev, A. S. Pankova, M. A. Kuznetsov
“Transition-Metal-Free Approach to 4-Ethynylpyrimidines via Alkenynones”
Eur. J. Org. Chem. 2014, 3614-3621
DOI: 10.1002/ejoc.201402045
A practical approach to the synthesis of 4-ethynylpyrimidines by the condensation of arylamidines with 2-aryl-1-ethoxy-5-(trimethylsilyl)pent-1-en-4-yn-3-ones has been developed. As these latter ketones are easily accessible from bis(trimethylsilyl)acetylene and arylacetyl chlorides, the regioselective condensation reported herein provides a facile access to both TMS-protected and unprotected 4-ethynylpyrimidines in yields of up to 85%.
