S. Miltsov, V. Karavan, A. Misharev, J. Alonso-Chamarro, M. Puyol
“Boron trifluoride–methanol complex. Mild and powerful reagent for deprotection of acetylated amines. Scope and selectivity”
Tetrahedron Lett., 2016, 57, 641-644
DOI:10.1016/j.tetlet.2015.12.087
A boron trifluoride–methanol complex demonstrated remarkable deprotection selectivity against commonly used amino-protecting groups in the deacetylation of acetanilides and high sensitivity to the steric hindrance of substrates. The scope and limitations of the reaction were explored.