Mendeleev Commun., 2017, 27, 95-96

G. P. Kantin, M. Yu. Krasavin

“Microwave-promoted reaction of N-alk-1-enyl chloroacetamides with sodium azide unexpectedly yields 1H-imidazol-5(4H)-ones”

Mendeleev Commun., 2017, 27, 95-96
DOI: 10.1016/j.mencom.2017.01.031

source: https://www.sciencedirect.com/science/article/pii/S0959943617300317?via%3Dihub

A novel method to prepare biologically relevant 1H-imidazol-5(4H)-ones from aliphatic amines, isobutyraldehyde, chloroacetyl chloride and sodium azide under microwave irradiation has been developed.

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