Tetrahedron Lett., 57, 641-644

S. Miltsov, V. Karavan, A. Misharev, J. Alonso-Chamarro, M. Puyol

“Boron trifluoride–methanol complex. Mild and powerful reagent for deprotection of acetylated amines. Scope and selectivity”

Tetrahedron Lett., 2016, 57, 641-644

A boron trifluoride–methanol complex demonstrated remarkable deprotection selectivity against commonly used amino-protecting groups in the deacetylation of acetanilides and high sensitivity to the steric hindrance of substrates. The scope and limitations of the reaction were explored.

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