A.E. Kulyashova, E.V. Mikheeva, N.A. Danilkina, I.A. Balova
“Synthesis of 2-(buta-1,3-diynyl)-N,N-dimethylanilines using reductive methylation step”
Mendeleev Commun., 2014, 24, 102-104
Synthesis of 2-(buta-1,3-diynyl)-N,N-dimethylanilines based on reductive methylation of ortho-iodoanilines using CH2O–NaBH3CN and coupling with terminal diacetylens was developed. Altered sequence including dimethylation of 2-(buta-1,3-diynyl)anilines was also successfully achieved and gave higher overall yields in the case of anilines without acceptor substituent in the ring.