English

Microporous and Mesoporous Materials, 2018, 220-228

Y.M. Zhukov, M.G. Shelyapina, I.A. Zvereva, A.Y. Efimov, V. Petranovskii

“Microwave assisted versus convention Cu2+ exchange in mordenite”

Microporous and Mesoporous Materials, 2018, 259, 220-228
DOI:10.1016/j.micromeso.2017.10.013

 source:https://www.sciencedirect.com/science/article/pii/S1387181117306662?via%3Dihub

Sodium mordenite was Cu2+-exchanged by conventional methods at ambient temperature (accepted as 20 °C) and with microwave radiation at 100 ± 1 °C. To increase the copper content, we repeat the exchange procedure several times. Both the degree of Cu2+ exchange and the environment of the Cu2+ ions depend on the method of exchange. Neither conventional, nor microwave methods do not destruct the topology of mordenite framework. XRD pattern of the mordenite persists, but slight elastic deformation and some dealumination of the surface layer occurs. For all the studied samples, all the copper ions are in Cu2+ state, neither Cu1+ nor Cu0 were detected. All the copper ions play the role of charge-balancing counter-cations. Their placement into the interior of zeolite causes the channel contraction due to electrostatic interactions of double charged cations with [AlO4]δ– units. The increase of copper content is accompanied by increasing of number of water molecules per unit cell. In fully hydrated samples the copper cations are effectively separated from the zeolite framework and are fully surrounded by a water ligand shell.

Конференция: Современное развитие магнитного резонанса

source:http://www.kfti.knc.ru/mdmr/2018/first-circular.php

C 24 по 28 сентября 2018 г. (Казань, Россия) пройдет очередная конференция “Modern Development of Magnetic Resonance 2018”

Org. Chem. Front., 2018, 226-231

M. S. Ledovskaya, K. S. Rodygina, V. P. Ananikov

“Calcium-mediated one-pot preparation of isoxazoles with deuterium incorporation”

Org. Chem. Front., 2018, 5, 226-231
DOI:10.1039/C7QO00705A

 source:http://pubs.rsc.org/en/Content/ArticleLanding/2018/QO/C7QO00705A#!divAbstract

In this work, a novel synthetic methodology for the one-pot preparation of isoxazoles directly from the reaction of calcium carbide with aldoximes is reported. Calcium carbide acts as a safe and inexpensive acetylene source and, in addition, as a source of the Ca(OH)2 base to enable the generation of nitrile oxide. Various 3-substituted isoxazoles were synthesized from the corresponding aldoximes in good yields (up to 95%) and a series of new deuterated 4,5-dideuteroisoxazoles were prepared.

Школа-конференция

source: http://mrschool2018.from-siberia.ru/

С 15 по 20 сентября 2018 г в Санкт-Петербурге пройдет V международная школа-конференция для молодых ученых “Магнитный резонанс и магнитные явления в химии и биофизике”. О конференции можно прочитать тут.

Int. J. Nanomedicine, 2018, 1471-1482

M. Shevtsov, B. Nikolaev, Y. Marchenko, L. Yakovleva, N.V. Skvorzov, A. Mazur, P. Tolstoy, V. Ryzhov, G. Multhoff

“Targeting experimental orthotopic glioblastoma with chitosan-based superparamagnetic iron oxide nanoparticles (CS-DX-SPIONs)”

Int. J. Nanomedicine, 2018, 13, 1471-1482
DOI: 10.2147/IJN.S152461

 

Glioblastoma is the most devastating primary brain tumor of the central nervous system in adults. Magnetic nanocarriers may help not only for a targeted delivery of chemotherapeutic agents into the tumor site but also provide contrast enhancing properties for diagnostics using magnetic resonance imaging (MRI)

ACS Biomater. Sci. Eng, 2018, 491-501

M. Promzeleva, T.V. Volkova, A.N. Proshin, O.I. Siluykov, A. Mazur, P.M. Tolstoy, S.P. Ivanov, F. Kamilov, I.V. Terekhova

“Improved biopharmaceutical properties of oral formulations of 1,2,4-thiadiazole derivative with cyclodextrins: in vitro and in vivo evaluation”

ACS Biomater. Sci. Eng, 2018, 4(2), 491-501
DOI: 10.1021/acsbiomaterials.7b00887

source: https://pubs.acs.org/doi/10.1021/acsbiomaterials.7b00887

The synthesized 1,2,4-thiadiazole derivative displaying biological activity has low aqueous solubility and dissolution rate. Novel oral formulations of thiadiazole with β- and hydroxypropyl-β-cyclodextrins were obtained by grinding and freeze-drying methods with the purpose to improve the aqueous solubility. Complex formation of 1,2,4-thiadiazole derivative with cyclodextrins was confirmed by means of solid-state 13C MAS CP/TOSS NMR. Solubility, dissolution rate and permeability of the solid inclusion complexes were evaluated in different biorelevant media (SGF, FaSSGF, FaSSIF) simulating the conditions in the gastrointestinal tract. It was demonstrated that the content of biorelevant media affects the properties of the inclusion complexes. In particular, solubilizing effect of cyclodextrins became less pronounced when the micelles of taurocholic acid and lecithin are formed in the dissolution media. The inclusion of thiadiazole into cyclodextrin cavity is in competition with its partitioning into the micelles and this should be taken into account when the in vivo behavior is predicted. The results of in vitro and in vivo experiments were found to be in agreement and showed the highest solubility, dissolution rate and bioavailability of the freeze-dried complexes of thiadiazole with hydroxypropyl-β-cyclodextrin. These complexes can be proposed as more effective dosage forms for oral administration.

J. Phys. Chem. C, 2018, 1711-1720

E.Yu. Tupikina, M. Bodensteiner, P.M. Tolstoy, G.S. Denisov, I.G. Shenderovich

“P=O Moiety as an Ambidextrous Hydrogen Bond Acceptor”

J. Phys. Chem. C, 2018, 122(3), 1711-1720
DOI: 10.1021/acs.jpcc.7b11299

source:https://pubs.acs.org/doi/10.1021/acs.jpcc.7b11299

Hydrogen bond patterns of crystals of phosphinic, phosphonic, and phosphoric acids and their cocrystals with phosphine oxides were studied using 31P NMR and single-crystal X-ray diffraction. Two main factors govern these patterns and favor or prevent the formation of cocrystals. The first one is a high proton-accepting ability of the P═O moiety in these acids. As a result, this moiety effectively competes with other proton acceptors for hydrogen bonding. For example, this moiety is a stronger proton acceptor than the C═O moiety of carboxylic acids. The second factor is the inclination of the P═O moiety of both the acids and the oxides to form two hydrogen bonds at once. The peculiarity of these bonds is that they weaken each other to a little degree only. In order to highlight this point, we are using the term “ambidextrous”. These two features should govern the interactions of P═O moiety with water and other proton donors and acceptors in molecular clusters, the active sites of enzymes, soft matter, and at surfaces.

Spinus 2018

source: http://spinus.spb.ru/С 1 по 6 апреля прошла очередная 15 школа-конференция Spinus 2018. Приятно отметить, что многие пользователи рц МРМИ и, собственно, сами сотрудники приняли активное участие в этой конференции. Среди сотрудников участвовали: М.А. Вовк, С.И. Сухаржеский, П.М. Толстой, А.С. Мазур. Среди пользователей рц МРМИ: В.И. Чижик, И.С. Гиба, А.В. Иевлев, М. Костин, Д.А. Лузик, Д.А. Маркелов, В.В. Малоярова, А.В. Пенькова, С.О. Рабдано, В. Барнаускайте.

Мы надеемся, что в будущем интерес к конференции Spinus среди пользователей рц МРМИ будет возрастать, и молодые исследователи будут активно апробировать свои работы и представлять их широкому кругу коллег.

Phys. Chem. Chem. Phys., 2018, 4901-4910

V.V. Mulloyarova, I.S. Giba, M.A. Kostin, G.S. Denisov, I.G. Shenderovich, P.M. Tolstoy

“Cyclic Trimers of Phosphinic Acids in Polar Aprotic Solvent: Symmetry, Chirality and H/D Isotope Effects on NMR Chemical Shifts”

Phys. Chem. Chem. Phys., 2018, 20, 4901-4910
DOI: 10.1039/C7CP08130H

The hydrogen-bonded self-associates of dimethylphosphinic (1), diphenylphosphoric (2), phenylphosphinic (3), and bis(2,4,4-trimethylpentyl)phosphinic (4) acids have been studied by using liquid-state NMR down to 100 K in a low-freezing polar solvent, CDF3/CDClF2. The H/D isotope effects on 1H NMR chemical shifts caused by partial deuteration of hydroxyl groups unambiguously reveal the stoichiometry of the self-associates and the cooperativity of their hydrogen bonds. In all cases, cyclic trimers are the dominant form, while cyclic dimers are present as a minor form for 1 and 2. Due to the asymmetry of substituents, cyclic trimers of 3 exist in two isomeric forms, depending on the orientation of the phenyl groups with respect to the plane of the hydrogen bonds. The racemic mixture of 4 leads to the coexistence of up to 64 isomers of cyclic trimers, many of which are chemically equivalent or effectively isochronous. The mole fractions of such isomers deviate from the statistically expected values. This feature could provide information about the relative stabilization energies of hydrogen-bonded chiral self-associates. The complexation of 4 with SbCl5 (complex 5) suppresses the self-association and 5 exists exclusively in the monomeric form with chemically non-equivalent 31P nuclei in RS, SR and RR/SS forms

Март

В Марте выполнено 2749 заявок на сервисные измерения.

Измерено:

  • 2596 спектр 1H
  • 462 спектра 13C
  • 157 спектров DEPT
  • 67 спектров COSY
  • 53 спектра NOESY
  • 111 спектра 31Р
  • 144 спектров 19F

Выполнено 299 заявок на исследовательскую работу.