Русский

Tetrahedron 2015, 71, 6196-6203

M.E. Chizhova, O.Yu. Bakulina, A.Yu. Ivanov, P.S. Lobanov, D.V. Dar’in

“Facile synthesis of pyrido[2,3-d]pyrimidines via cyclocondensation of 4,6-dichloro-2-methylsulfanylpyrimidine-5-carbaldehyde with β-substituted β-aminoacrylic esters”

Tetrahedron, 2015, 71, 6196-6203

DOI:10.1016/j.tet.2015.06.085

A new facile synthesis of pyrido[2,3-d]pyrimidin-4-ones via cyclocondensation of 4,6-dichloro-2-methylsulfanylpyrimidine-5-carbaldehyde with β-alkyl and β-aryl-β-aminoacrylic esters followed by hydrolysis of chlorine atom at position 4 of pyridopyrimidine ring has been developed. The cyclocondensation was found to be accelerated by acid.

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