Center for Magnetic Resonance

D.V. Dar’in, А.Yu. Ivanov, P.S. Lobanov

“Cyclocondensation of Ethyl (imidazolidine-2-ylidene)acetate with Aromatic Esters Bearing Labile Halogen in ortho-Position”

J. Hetercyclic Chem., 2015, 52, 1192-1194

DOI:10.1002/jhet.2229

Cyclocondensation of ethyl (imidazolidine-2-ylidene)acetate with aromatic esters bearing labile halogen in ortho-position leads to fused heterocycles, which is formed by substitution of halogen atom with α-carbon atom of cyclic ketene aminal and binding of nitrogen atom with carbonyl carbon atom of aromatic ester.

M.E. Chizhova, O.Yu. Bakulina, A.Yu. Ivanov, P.S. Lobanov, D.V. Dar’in

“Facile synthesis of pyrido[2,3-d]pyrimidines via cyclocondensation of 4,6-dichloro-2-methylsulfanylpyrimidine-5-carbaldehyde with β-substituted β-aminoacrylic esters”

Tetrahedron, 2015, 71, 6196-6203

DOI:10.1016/j.tet.2015.06.085

A new facile synthesis of pyrido[2,3-d]pyrimidin-4-ones via cyclocondensation of 4,6-dichloro-2-methylsulfanylpyrimidine-5-carbaldehyde with β-alkyl and β-aryl-β-aminoacrylic esters followed by hydrolysis of chlorine atom at position 4 of pyridopyrimidine ring has been developed. The cyclocondensation was found to be accelerated by acid.