Archive for August 29, 2014

Mendeleev Commun. 2014

O.Yu. Bakulina, A.Yu. Ivanov, D.V. Dar’in, P.S. Lobanov

“New transformations of 2-methylsulfanyl-4,6-dichloropyrimidine-5-carbaldehyde involving enamines: synthesis of condensed azines”

Mendeleev Commun 2014, 24, 163-164

DOI: 10.1016/j.mencom.2014.04.013

The reaction between 4,6-dichloropyrimidine-5-carbaldehyde and methyl 3-aminocrotonate leads to pyrido[2,3-d]pyrimidine which reacts with ethyl 3,3-diaminoacrylate to give pyrimido[4,5,6-de][1,6]naphthyridine derivative. The structure of the latter was confirmed by XRD analysis.

Tetrahedron Lett. 2014

D.S. Ryabukhin, L.Yu. Gurskaya, G.K. Fukin, A.V. Vasilyev

“Superelectrophilic activation of N-aryl amides of 3-arylpropynoic acids: synthesis of quinolin-2(1H)-one derivatives”

Tetrahedron Lett., 2014, 70, 6428-6443

DOI: 0.1016/j.tet.2014.07.028
Tetrahedron lett 2014 gr ab

The superelectrophilic activation of N-aryl amides of 3-arylpropynoic acids by Bronsted superacids (CF3SO3H, HSO3F) or strong Lewis acids AlX3 (XјCl, Br) results in the formation of 4-aryl quinolin-2(1H)-ones in quantitative yields. The vinyl triflates or vinyl chlorides may be formed as additional reaction products. The investigated amides in reactions with benzene give 4,4-diaryl 3,4-dihydroquinolin-2-(1H)-ones under the superelectrophilic activation. 4-Aryl quinolin-2(1H)-ones in POCl3 are converted into 4-aryl 2-chloroquinolines. 4-Fluorophenyl-4-phenyl 3,4-dihydroquinolin-2-(1H)-one give N-formylation products in a yield of 79% under the VilsmeiereHaack reaction conditions.

Fewer and fewer

Гуринов Андрей

Today Andrey Gurinov quit the Center. We wish him all the best on his is new job!

Tetrahedron Letters, 2014

A.V. Stepakov, V.M. Boitsov, A.G. Larina, A.P. Molchanov

”Acid-induced rearrangement of cycloadducts from N-aryl itaconimides and 1,3-diphenylisobenzofuran”

Tetrahedron Lett., 2014, accepted

DOI: 10.1016/j.tetlet.2014.06.107


Treatment of several Diels–Alder adducts of N-aryl itaconimides and 1,3-diphenylisobenzofuran with a strong acid triggers a skeletal rearrangement resulting in 2-aryl-6,10b-diphenylbenzo[h]isoquinoline-1,3(2H,10bH)-diones.

Analytical Lett. 2014

Dz.N. Konshina, A.V. Furina, Z.A. Temerdashev, A.A. Gurinov, V.V. Konshin

“Immobilization of Guanazyl Functional Groups on Silica for Solid-Phase Extraction of Metal Ions”

Analytical Lett. 2014, accepted

DOI: 10.1080/00032719.2014.917421

Guanazyl groups were grafted on silica gel by 4-nitrobenzoyl chloride acylation, sodium dithionite reduction, diazotation, and reaction with 2-benzylidenehydrazinecarboximidamide. The modified silica gel was used for separation and preconcentration of Cu(II), Ni(II), Cd(II), and Co(II). Quantitative extraction of the ions was achieved after 30 min and at the optimal pH of 7.5-8 at an initial concentration of 2 mg L−1. Analysis of metal sorption isotherms allowed estimation of the sorbent’s interaction efficacy under static conditions at optimal pH. Distribution coefficients were determined to be 3 ± 0.3 L g−1 for Ni(II), 3 ± 0.3 L g−1 for Co(II), 1.6 ± 0.2 L g−1 for Cd(II), and 4.6 ± 0.4 L g−1 for Cu(II) at 20-60 µg analyte. The applicability of pseudo-second order kinetic equations for metal sorption kinetics description was investigated. Chemically modified silica was used for solid-phase extraction of the metal ions to improve the detection limit using X-ray fluorescence spectrometry. The method was employed for the determination of Cu(II) in water with a low limit of detection, high accuracy, and good precision.


The numbers keep thinning out

Today, Anastasia Kultaeva quit the Center. We wish her all the best on her new job!

Science by “Argumenty i Fakty”

face palm

Readers of “Science” column in the “Argumenty i Fakty” may learn that “The Silmarillion” is an ancient scripture, on which “The Lord of the Rings” is based; that 13 000 years ago island of Númenor drowned in the Bermuda Triangle; that the One Ring rests at the bottom of Loch-Ness where the famous monster still guarding it.

Ufa scientists led by Professor Ernst Muldashev reveal secrets of the past (Russian only).

July 2014

Total in July 991 service applications were carried out.

All together measured:

  • 952 1H spectra
  • 221 13C spectra
  • 146 DEPT spectra
  • 17 COSY spectra
  • 3 NOESY spectra
  • 46 31P spectra
  • 42 19F spectra

68 applications were carried out which jointly took 653 hours of measurements.