Tag Archive for Толстой

J. Polym. Sci., Part A: Polym. Chem., 2018, 56, 387–398

V.A. Rozentsvet, O.A. Stotskaya, V.P. Ivanova, M.G. Kuznetsova, P.M. Tolstoy, S.V. Kostjuk

“Structural characterization of polybutadiene synthesized via cationic mechanism”

J. Polym. Sci., Part A: Polym. Chem., 2018, 56, 387–398.
DOI: 10.1002/pola.28905

source: http://onlinelibrary.wiley.com/doi/10.1002/pola.v56.4/issuetoc

The microstructure of polybutadiene synthesized via cationic polymerization using TiCl4-based initiating systems has been investigated using 1D (1Н, 2Н, and 13С) and 2D (HSQC and HMBC) NMR spectroscopy. It was found that trans-1,4-unit is predominant structure of unsaturated part of polymer chain. Besides, the small amount of 1,2-structures was also detected, while cis-1,4-units were totally absent. The signals of carbon atoms of three types of head groups (trans-1,4-, 1,2-, and tert-butyl) and two types of end groups (trans-1,4-Cl and 1,2-Cl) were identified for the first time in macromolecules of cationic polybutadiene. It was showed that tert-butyl head groups were formed due to the presence in monomer of admixtures of isobutylene. The new methodology for calculation of the content of different structural units in polybutadiene chain as well as the head and end groups was proposed. It was established that main part of 1,2-units distributed randomly along the polybutadiene chain as separate units between trans-1,4-structures.


Dalton Transactions, 2017, 46, 12425-12429

A.V. Artem’ev, I.Yu. Bagryanskaya, E.P. Doronina, P.M. Tolstoy, A.L. Gushchin, M.I. Rakhmanova, A.Yu. Ivanove, A.O. Suturina

“A new family of clusters containing a silver-centered tetracapped [Ag@Ag4(μ3-P)4] tetrahedron, inscribed within a N12 icosahedron”

Dalton Transactions, 2017, 46, 12425-12429.
DOI: 10.1039/C7DT02597A

source: http://pubs.rsc.org/en/Content/ArticleLanding/2017/DT/C7DT02597A#!divAbstract

An unprecedented silver-centered P-tetracapped [Ag@Ag4(μ3-P)4] tetrahedron inscribed within a N12 icosahedral cage has been discovered in the novel family of luminescent clusters. The latter are easily self-assembled by reacting AgI salts with tris(2-pyridyl)phosphine (Py3P).


Carbohydrate Polymers, 2017, 169, 117–126

N.G. Voron’ko, S.R. Derkach, M.A. Vovk, P.M. Tolstoy

“Complexation of κ-carrageenan with gelatin in the aqueous phase analysed by 1H NMR kinetics and relaxation”

Carbohydrate Polymers, 2017, 169, 117–126
DOI: 10.1016/j.carbpol.2017.04.010

The 1H NMR spectroscopy is used to study the kinetics of gelation in the aqueous mixtures of κ-carrageenan with gelatin. The time dependence of NMR signals intensities shows that the kinetics of gel formation consists of classical ‘fast’ (rate constant k ≈ 6 h−1) and ‘slow’ (k ≈ 1 h−1) periods, corresponding to a coil → helix transition and subsequent aggregation of helices. Upon increase of the κ-carrageenan/gelatin (w/w) ratio Z the rate of the fast process slows down by a factor of 1.6–2.4. Further analysis was done by studying the dependence of spin-spin relaxation times of protons of gelatin on Z in the aqueous phase. A qualitative scheme describing hydrogel formation in the complex solution is given. It is hypothesized that at higher concentration of PECs the hydrogel structure network is stabilized by three types of nodes: triple helices of gelatin and intra-/inter-molecular double helices of κ-carrageenan.

J Therm Anal Calorim, 2017

M. Brusnikina, O. Silyukov, M. Chislov, T. Volkova, A. Proshin, A. Mazur, P. Tolstoy, I. Terekhova

“Effect of cyclodextrin complexation on solubility of novel anti-Alzheimer 1,2,4-thiadiazole derivative”

J Therm Anal Calorim, 2017
DOI: 10.1007/s10973-017-6252-1

источник: https://link.springer.com/journal/10973

New 1,2,4-thiadiazole derivative displaying neuroprotective potential and high activity in the treatment of Alzheimer’s disease has been synthesized. The objective of this study was to improve the aqueous solubility of this drug-like compound by means of complex formation with native and hydroxypropylated β-cyclodextrins. To this end, aqueous solubility of 1,2,4-thiadiazole derivative was investigated in the presence of β-cyclodextrins. It was shown that the phase solubility diagrams are of Bs type demonstrating the initial increase in thiadiazole solubility in solutions of cyclodextrins (concentration up to 0.01 mol kg−1) followed by a solubility decrease due to the precipitation of the complexes formed. In comparison with β-cyclodextrin, hydroxypropyl-β-cyclodextrin displays more pronounced solubilizing action since it forms more stable complexes with thiadiazole. Solid complexes of 1,2,4-thiadiazole derivative with β-cyclodextrins were prepared by grinding and freeze-drying methods. DSC, TG, hot-stage microscopy, solid-state 13C MAS CP/TOSS NMR, powder X-ray diffractometry and FTIR spectroscopy were used to prove the existence of complexes in the solid state. Solubility of the obtained formulations was also examined. It was found that complexes of thiadiazole with hydroxypropyl-β-cyclodextrin exhibited higher solubility in phosphate buffer (pH 7.4) compared with pure thiadiazole and its complexes with β-cyclodextrin.


Обзорная экскурсия, посвященная деятельности РЦ МРМИ, проведена для делегации из посольства Тайланда.

Участиники конференции Менделеев-2017

Поток гостей и участников конференции Менделеев-2017 в РЦ МРМИ продолжается. Нас радуют возникающие у гостей вопросы о механизмах сотрудничества и “первых шагах”, необходимых для начала практической деятельности на базе Научного Парка СПбГУ в РЦ МРМИ. Надеемся, что краткие вводные экскурсии, в ходе которых мы рассказываем об оборудовании и возможностях РЦ, добавят в наши ряды новых пользователей с их новыми проектами и задачами.



На базе Санкт-Петербургского государственного университета 4–7 апреля 2017 г проходит конференция Менделеев-2017.  Для участников конференции организованы экскурсии в РЦ МРМИ, Наши сотрудники демонстрируют возможности РЦ и расказывают о различных текущих проектах и решаемых экспериментальных задачах.

Рабочая встреча

В рамках запланированной рабочей встречи РЦ МРМИ посетили представителей ГК “Росатом”, ПИЯФ, СПбГУ. В ходе демонстрационной экскурсии проходило обсуждение образовательных программ магистратуры и аспирантуры, возможностей рц для создания направленных курсов для обучающихся и стажирующихся студентов.