Archive for Публикации

J Therm Anal Calorim, 2017

M. Brusnikina, O. Silyukov, M. Chislov, T. Volkova, A. Proshin, A. Mazur, P. Tolstoy, I. Terekhova

“Effect of cyclodextrin complexation on solubility of novel anti-Alzheimer 1,2,4-thiadiazole derivative”

J Therm Anal Calorim, 2017
DOI: 10.1007/s10973-017-6252-1

источник: https://link.springer.com/journal/10973

New 1,2,4-thiadiazole derivative displaying neuroprotective potential and high activity in the treatment of Alzheimer’s disease has been synthesized. The objective of this study was to improve the aqueous solubility of this drug-like compound by means of complex formation with native and hydroxypropylated β-cyclodextrins. To this end, aqueous solubility of 1,2,4-thiadiazole derivative was investigated in the presence of β-cyclodextrins. It was shown that the phase solubility diagrams are of Bs type demonstrating the initial increase in thiadiazole solubility in solutions of cyclodextrins (concentration up to 0.01 mol kg−1) followed by a solubility decrease due to the precipitation of the complexes formed. In comparison with β-cyclodextrin, hydroxypropyl-β-cyclodextrin displays more pronounced solubilizing action since it forms more stable complexes with thiadiazole. Solid complexes of 1,2,4-thiadiazole derivative with β-cyclodextrins were prepared by grinding and freeze-drying methods. DSC, TG, hot-stage microscopy, solid-state 13C MAS CP/TOSS NMR, powder X-ray diffractometry and FTIR spectroscopy were used to prove the existence of complexes in the solid state. Solubility of the obtained formulations was also examined. It was found that complexes of thiadiazole with hydroxypropyl-β-cyclodextrin exhibited higher solubility in phosphate buffer (pH 7.4) compared with pure thiadiazole and its complexes with β-cyclodextrin.

Czech Polar Reports, 2017, 7, 1-10

E. Abakumov

“Characterisation of humic acids, isolated from selected subantarctic soils by 13C-NMR spectroscopy”

Czech Polar Reports, 2017, 7(1), 1-10
DOI: 10.5817/CPR2017-1-1

Soils of Antarctic considered as underestimated in terms of soils organic matter polls, organic remnants humification/mineralization rates and biogenic-abiogenic interactions. Humic acids of selected Sub Antarctic soils were investigated in terms of elemental and structural composition with special reference to evaluation of organic matter stabilisation degree and assessment of carbon species distributions in the molecules with use of solid state 13C-NMR spectroscopy. It was shown, that the prevailing of aliphatic compounds on the aromatic one is more pronounced in Antarctic soils than in Arctic ones. Average portion of the aromatic compounds is about 20% in humic acids, extracted from soils with evident ornitogenic effect from Fildes Peninsula (Norh-West Antarctic peninsula). This indicates that the role of humification precursors composition is the leading in the humification process. The stabilisation rate of the Antarctic HAs can be assessed as low and the potential risk of biodegradation of their molecules are high.

Applied Catalysis: A, 2017, 542, 350-358

P. Mäki-Arvela, J. Zhu, N. Kumar, K. Eränen, A. Aho, J. Linden, J. Salonen, M. Peurla, A. Mazur, V. Matveev, D. Y. Murzin

“Solvent-free “green” amidation of stearic acid for synthesis of biologically active alkylamides over iron supported heterogeneous catalysts”

Applied Catalysis: A, 2017, 542, 350-358
DOI: 10.1016/j.apcata.2017.06.006

Stearoyl ethanolamine was synthesized by amidation of stearic acid with ethanolamine in solventless conditions. Iron containing heterogeneous catalysts supported on SiO2, Al2O3, Beta (BEA), ZSM-12 (MTW) and Ferrierite (FER) were used in this work. Sn-modified Ferrierite and H-Ferrierite were also studied for comparison. Fe-modified catalysts synthesized using solid state ion-exchange and evaporation impregnation methods, were thoroughly characterized with X-ray powder diffraction, scanning electron microscope, FTIR with pyridine, nitrogen adsorption, energy dispersive X-ray microanalysis and Mössbauer spectroscopy. The highest conversion was obtained with Fe-H-FER-20 at 140 °C in 1 h giving 61% conversion and 98% selectivity towards the desired amide. The catalytic performance in terms of turnover frequency per mole of iron was achieved with the catalyst exhibiting the largest amount of Fe3+ species, optimum acidity and a relatively low Brønsted to Lewis acid site ratio.

RSC Adv., 2017, 7, 10070-10073

A.S. Smirnov, D.N. Nikolaev, V.V. Gurzhiy, S.N. Smirnov, V.S. Suslonov, A.V. Garabadzhiu, P.B. Davidovich

“Conformational stabilization of isatin Schiff bases – biologically active chemical probes”

RSC Adv., 2017, 7, 10070-10073
DOI: 10.1039/c6ra26779c
источник: http://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C6RA26779C#!divAbstract

Isatin Schiff base derivatives have a wide range of biological effects. Unfortunately, these compounds possess a serious topological shortcoming: the conformational E ⇆ Z interconversion. Two ways of conformation stabilization are reported here: complexation with metals that stabilize the E-conformer and substitution in the 4th position of the isatin core stabilizing the Z-form.

Eur. J. Org. Chem., 2017, 2587-2595

A. Stukalov, V.V. Sokolov, V.V. Suslonov, M.A. Kuznetsov

“Pyrazoles and C-Imidoylaziridines through [4+1] Annulation and [2+1] Cycloaddition of 1-Azabuta-1,3-dienes with a Synthetic Equivalent of Phthalimidonitrene”

Eur. J. Org. Chem., 2017, 2587-2595
DOI: 10.1002/ejoc.201700172

Oxidative addition of N-aminophthalimide to 1,2,4-triaryl-1-azabuta-1,3-dienes leads, in most cases, to the regiodefined formation of 1,3,5-triarylpyrazoles in moderate to good yields through [4+1] annulation. This transformation is supposed to proceed by nitrenoid attack onto a lone pair of electrons of the imine nitrogen atom to give the vinylazomethine imine, followed by its 1,5-electrocyclization into pyrazoline and further aromatization into pyrazole. Rare examples of 2-imidoyl-1-phthalimidoaziridines that are formed by competitive [2+1] cycloaddition onto the C=C bond were isolated in low yields for 1-azadienes with electron-deficient aryl substituents at the imine nitrogen atom.

Tetrahedron Lett., 2017, 58, 172-174

M.A. Kuznetsov, A.N. Shestakov, M. Zibinsky, M. Krasavin, C.T. Supuran, S. Kalinin, Muhammet Tanç

“Synthesis, structure and properties of N-aminosaccharin — A selective inhibitor of human carbonic anhydrase I”

Tetrahedron Lett., 2017, 58, 172-174

Previously unknown N-aminosaccharin was prepared in good yield via the one-step direct amination of saccharin sodium salt with hydroxylamine-O-mesitylenesulfonic acid (MSH) and its reactivity investigated. N-aminosaccharin and its derivatives were tested against hCA isoforms and the parent compound was identified to be a selective, low micromolar inhibitor (Ki = 8.8 μM) of hCA I. These findings provide a ligand-efficient starting point for the design of potent hCA I inhibitors – a promising drug target for retinal/cerebral edema treatment.

Tetrahedron, 2017, 73, 3939-3948

A.N. Shestakov, A.S. Pankova, P.Golubev, A.F. Khlebnikov, M.A. Kuznetsov

“Brønsted acid mediated cyclizations of ortho-aryl(ethynyl)pyrimidines”

Tetrahedron, 2017, 73, 3939-3948
источник: http://www.sciencedirect.com/science/article/pii/S0040402017305719

A high-yielding procedure for the synthesis of 5-aryl-4-(arylethynyl)pyrimidines from easily available 2-aryl-3-hydroxyacrylates is reported. These pyrimidines readily undergo cyclization in strong Brønsted acids and, depending on the substitution in alkynylpyrimidines and the water content of the reaction mixture, yield either benzo[f]quinazolines or derivatives of spiro[cyclohexa-2,5-diene-1,5′-cyclopenta[d]pyrimidin]-4-one. In most cases the cyclization proceeds nearly quantitatively. DFT calculations support the proposed mechanisms induced by the protonation of the triple bond in 5-aryl-4-(arylethynyl)pyrimidines. Fluorescent properties of the obtained heterocycles are also described.


Неорганические Материалы, 2017, 53, 1-9

Е.А. Чалая, А.Г. Тюрин, М.В. Васеха, А.И. Бирюков, С.М. Сухаржевский

“Синтез и свойства двойного сульфита меди(I)–кобальта (II)”

Неорганические Материалы, 2017, 53(9), 1-9

источник: http://www.naukaran.com/zhurnali/katalog/neorganicheskie-materialy/

Уточнены диаграммы Пурбе систем Сu–Н2SO4–H2O и Co–H2SO4–H2O, в них определены области устойчивости сульфитных фаз. Построены диаграммы состояния двойных сульфитов меди(I)-меди(II), меди(I)-кобальта(II). Из водного раствора, насыщенного диоксидом серы, выделены двойные сульфиты: Cu2SO3 · СuSO3, Cu2SO3 · CoSO3. Получены спектры электронного парамагнитного резонанса, выполнены рентгенофазовый, ИК-спектроскопический, дисперсионный и термический анализы выделенного двойного сульфита CoSO3 · Cu2SO3. Заложена основа термодинамического прогнозирования синтеза двойных сульфитов состава Cu2SO3 · MSO3 (М – Cu, Co).


Geosciences, 2017, 7, 24

A. Lupachev, E. Abakumov, S. Gubin

“The Influence of Cryogenic Mass Exchange on the Composition and Stabilization Rate of Soil Organic Matter in Cryosols of the Kolyma Lowland (North Yakutia, Russia)”

Geosciences, 2017, 7, 24

Источник: http://www.mdpi.com/2076-3263/7/2/24

Soil organic matter (SOM) was studied in different types of organo-mineral material (from surface horizons and partially isolated materials—cryoturbated or buried horizons) sampled from the surface horizons, the central parts of the Cryosol profiles, and the lower active layer. We found that the humic acids (HAs) of the cryoturbated and buried horizons showed an increased degree of oxidation and an increment of alkylaromatic and protonized aromatic fraction content. In contrast, the HAs of the surface horizons showed increased values of alkylic carbon components. The content of free radicals was essentially higher in the surface layers than in the cryoturbated and buried layers. While the bulk soil organic matter composition (total organic carbon, total nitrogen, and aromatic/aliphatic values) was not essentially different between surface, cryoturbated, and buried horizons, there were essential differences in elemental composition, carbon species, and free radical content. This indicates that the degree of humification in cryoturbated and buried organo-mineral material is higher than in surface horizons and that partial isolation results in relative stabilization of such material in soil profiles.


Оптика и Спектроскопия, 2017,122(3), 436-444

Е.А. Катленок, С.Н. Смирнов, А.Ю. Иванов, С.В. Макаренко, К.П. Балашев

“Влияние донорно-акцепторных свойств лигандов на спектроскопические и электрохимические характеристики смешанно-лигандных циклометаллированных комплексов Pt(II) и Ir(III) 2-фенилбензотиазола”

Оптика и Спектроскопия, 2017,122(3), 436-444
Приведены результаты спектроскопических ЯМР 1Н, 13C, 195Pt, ИК, оптических и вольтамперометрических характеристик смешанно-лигандных комплексов Pt(II) и Ir(III) с металлированным 2-фенилбензотиазолом и трет-бутилизоцианидом (tBuNC), ацетонитрилом (AN), этилендиамином(En), О-этилдитиокарбонат- (Exn–) и диэтилдитиокарбонат-ионами (Dtc–). Показано, что изменение донорно-акцепторного взаимодействия с металлом лигандов tBuNC, AN, En, Exn–, Dtc– приводит к повышению энергии высшей заполненной молекулярной орбитали комплексов и сопровождается катодным смещением потенциала металл-центрированного окисления, батохромным смещением спин-разрешенного и спин-запрещенного оптических переходов переноса заряда металл-циклометаллированный лиганд и увеличением степени смешивания 1ПЗМЛ- и триплетного внутрилигандного состояния, ответственного за фосфоресценцию комплексов.