Archive for 29.11.2016

New J. Chem., 2016, 40, 10028-10040

A.V. Artem’ev, E.P. Doronina, M.I. Rakhmanova, A.O. Sutyrina, I.Yu. Bagryanskaya, P.M. Tolstoy, A.L. Gushchin, A.S. Mazur, N.K. Gusarova, B.A. Trofimov

“Luminescent CuI thiocyanate complexes based on tris(2-pyridyl)phosphine and its oxide: from mono-, di- and trinuclear species to coordination polymer”

New J. Chem., 2016, 40, 10028-10040


Tris(2-pyridyl)phosphine oxide reacts with CuSCN to form a variety of luminescent complexes, depending on the specified metal-to-ligand ratio and the solvent used, viz. mononuclear [Cu(N,N′,N′′-Py3P=O)(NCS)], dinuclear (N,N′-Py3P=O)Cu(SCN NCS)Cu[(N,N′-Py3P=O)], their co-crystal (2 : 1, correspondingly) and trinuclear {Cu(NCS)[SCNCu(N,N′,N′′-Py3P=O)]2}. In the solid state, these complexes feature red-orange emission upon UV photoexcitation. The reaction of tris(2-pyridyl)phosphine with CuSCN quantitatively produces an almost insoluble coordination polymer, [Cu(Py3P)NCS]n, which exhibits bright green emission. The synthesized compounds are the first members of the hitherto unknown family of Cu(I) thiocyanate complexes supported by tripodal ligands.



Обзорная экскурсия для студентов-бакалавров 4 курса химического факультета. П.М. Толстой провел вводную лекцию для наших посетителей, М.А. Вовк, А.С. Мазур, С.М. Сухаржевский провели демонстрацию ЯМР, ЯКР и ЭПР спектрометров.

Tetrahedron Lett., 2016, 57, 5192-5196

M.N. Putintseva, O.Yu. Bakulina, A.Yu. Ivanov, P.S. Lobanov, S.K. Nikolskaya, I.E. Kolesnikov, D.V. Dar’in

“Double tandem cyclization of 4-(1-acyl-2,2-diaminovinyl)-6-arylpyrimidine-5-carbonitriles. Synthesis of novel peri-annulated azines”

Tetrahedron Lett., 2016, 57, 5192-5196

A series of novel peri-fused azines, pyrimido[4,5,6-de]quinolino[2,3-b][1,8]naphthyridines and benzo[b]pyrimido[4,5,6-de][1,8]naphthyridines, were prepared via the base-promoted double tandem cyclization of 4-(1-acyl-2,2-diaminovinyl)-6-(haloaryl)pyrimidine-5-carbonitriles. This transformation represents a rare example of the one-pot synthesis of peri-annulated polycyclic structures from non-fused heterocycles. The synthesized pyrimido[4,5,6-de]quinolino[2,3-b][1,8]naphthyridines were found to be luminophores.


Д-р Константинос Сотириадис, институт теоретической и прикладной механики, Академия наук Чехии представил доклад о своей научной деятельности и работе, проделанной в РЦ МРМИ.


Сегодня РЦ МРМИ посетили участники зимней школы-конференции Spinus-2016. Для гостей РЦ проведена обзорная экскурсия, в рамках которой представлено современное оборудование, применяемое в областях спектроскопии ЯМР, ЭПР, ЯКР. В ходе экскурсии приведены примеры некоторых экспериментальных задач, решаемых в РЦ МРМИ. В понедельник, 21.11.16, П. М. Толстой прочел участникам конференции Spinus-2016 лекцию «Изучение кооперативности водородных связей методами жидкостной спектроскопии ЯМР».

J. Org. Chem., 2016, 81, 11210-11221

L.D. Funt, O.A. Tomashenko, A.F. Khlebnikov M.S. Novikov, A.Yu. Ivanov

“Synthesis, Transformations of Pyrrole- and 1,2,4-Triazole-Containing Ensembles, and Generation of Pyrrole-Substituted Triazole NHC”

J. Org. Chem., 2016, 81, 11210-11221

Unprecedented pyrrole- and 1,2,4-triazole-containing ensembles, substituted 1-(1H-pyrrol-3-yl)-4H-1,2,4-triazol-1- ium bromides and 4-(1H-pyrrol-3-yl)-1H-1,2,4-triazol-4-ium bromides, were prepared from 2H-azirines and triazolium phenacyl bromides using a simple procedure. N-(1H-Pyrrol-3-yl)-N′-benzyltriazolium bromides undergo reductive debenzylation on Pd/C to give substituted 1-(1H-pyrrol-3-yl)-4H-1,2,4-triazoles and 4-(1H-pyrrol-3-yl)-1H-1,2,4-triazoles in high yields. Betaines (triazoliumylpyrrolides) and pyrrolyltriazole NHCs, which are possible products of dehydrobromination of pyrrolyltriazolium salts, have comparable thermodynamic stabilities in nonpolar solvents according to calculations at the DFT B3LYP/6-31G(d) level. The carbene forms can be easily trapped by the reaction of salts with base in the presence of sulfur. The corresponding 1- and 4-(1H-pyrrol-3-yl)-1H-1,2,4-triazole-5(4H)-thiones are formed in high yields. In the absence of sulfur as a trap, the opening of the triazole ring occurs with the formation of derivatives of N-cyanoformimidamide. According to the DFT calculations the latter is most probably formed via a pyrrolyltriazoliumide intermediate, which is the minor component of the equilibrium triazoliumylpyrrolide−pyrrolyltriazole NHC−pyrrolyltriazoliumide. Blocking of the pyrrolyltriazoliumide intermediate formation, by introduction of a substituent at the 3-position of the triazole ring, made it possible to generate the first pyrrole-substituted triazole NHC.


Курс спектроскопии ЯМР

Сегодня в РЦ МРМИ состоялось завершающее занятие серии лекций о современных методах спектроскопии ядерного магнитного резонанса в органической химии, проведенных для сотрудников компании BIOCAD. В ходе занятия была проведена демонстрация работы на современном оборудовании.

Eur. J. Inorg. Chem., 2016, 28, 4659-4667

E.A. Popova, T.V. Serebryanskaya, S.I. Selivanov, M. Haukka, T.L. Panikorovsky, V.V. Gurzhiy, I. Ott, R.E. Trifonov, V.Yu. Kukushkin

“Water soluble platinum(II) complexes featuring 2-alkyl-2H-tetrazol-5-ylacetic acids: synthetic, X-ray diffraction, and solution NMR studies”

Eur. J. Inorg. Chem., 2016, 28, 4659-4667

source of image: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0682c

2-R-2H-Tetrazol-5-ylacetic acids (abbreviated as 2-R-taa; R = Me, iPr, tBu) react with K2[PtCl4] in 1 m HCl in H2O at r.t. furnishing trans-platinum(II) complexes trans-[PtCl2(2-R-taa)2] (1–3), whereas cis-isomeric species cis-[PtCl2(2-R-taa)2] (R = iPr, 4; tBu, 5) are isolated at lower temperature (4–6 °C). In the presence of EtOH in the reaction mixture, esterification of the tetrazol-5-ylacetoxy group of 2-tBu-taa leads to trans-[PtCl2(ethyl 2-tert-butyl-2H-tetrazol-5-ylacetate)2] (6). Complexes 1–6 were characterized by elemental analyses (CHN), HRESI+-MS, 1H, 13C{1H}, 195Pt{1H} NMR and IR spectroscopy, differential scanning calorimetry/thermogravimetry (DSC/TG), and X-ray diffraction (for 1·H2O, 2, 3·2H2O, 4, 5·2H2O, and 6). The generation of the tetrazole-based complexes in solution (1 m DCl in D2O, 25 °C) was studied by 1H NMR spectroscopy and HPLC-MS. The obtained data indicate the initial formation of anionic [PtCl3(2-R-taa)]– complexes that are subsequently converted into disubstituted isomeric platinum(II) species cis- and trans-[PtCl2(2-R-taa)2]. By contrast to cis- and trans-[PtCl2(2-R-taa)2] that were inactive in two human cancer models in vitro (IC50 > 100 µm), complex 6 demonstrated noticeable antiproliferative effects in HT-29 colon and MCF-7 breast carcinoma cell lines with IC50 values of 14.2 ± 1.1 and 5.8 ± 1.2 µm, respectively.



source of image: http://eu.wiley.com/WileyCDA/WileyTitle/productCd-3527330003.html

В РЦ МРМИ прошло первое из двух занятий со студентами 2-го курса химического факультета по ознакомлению со спектрометрами ядерного магнитного резонанса.

J. Am. Chem. Soc., 2016, 138, 14129-14137

A.S. Mikherdov, M.A. Kinzhalov, A.S. Novikov, V.P. Boyarskiy, I.A. Boyarskaya, D.V. Dar’in, G.L. Starova, V.Yu. Kukushkin

“Difference in energy between two distinct types of chalcogen bonds drives regioisomerization of binuclear (Diaminocarbene)PdII complexes”

J. Am. Chem. Soc., 2016, 138, 14129-14137

The reaction of cis-[PdCl2(CNXyl)2] (Xyl = 2,6-Me2C6H3) with various 1,3-thiazol- and 1,3,4-thiadiazol-2-amines in chloroform gives a mixture of two regioisomeric binuclear diaminocarbene complexes. For 1,3-thiazol-2-amines the isomeric ratio depends on the reaction conditions and kinetically (KRs) or thermodynamically (TRs) controlled regioisomers were obtained at room temperature and on heating, respectively. In CHCl3 solutions, the isomers are subject to reversible isomerization accompanied by the cleavage of Pd–N and C–N bonds in the carbene fragment XylNCN(R)Xyl. Results of DFT calculations followed by the topological analysis of the electron density distribution within the formalism of Bader’s theory (AIM method) reveal that in CHCl3 solution the relative stability of the regioisomers (ΔGexp = 1.2 kcal/mol; ΔGcalcd = 3.2 kcal/mol) is determined by the energy difference between two types of the intramolecular chalcogen bonds, viz. S···Cl in KRs (2.8–3.0 kcal/mol) and S···N in TRs (4.6–5.3 kcal/mol). In the case of the 1,3,4-thiadiazol-2-amines, the regioisomers are formed in approximately equal amounts and, accordingly, the energy difference between these species is only 0.1 kcal/mol in terms of ΔGexp (ΔGcalcd = 2.1 kcal/mol). The regioisomers were characterized by elemental analyses (C, H, N), HRESI+-MS and FTIR, 1D (1H, 13C{1H}) and 2D (1H,1H-COSY, 1H,1H-NOESY, 1H,13C-HSQC, 1H,13C-HMBC) NMR spectroscopies, and structures of six complexes (three KRs and three TRs) were elucidated by single-crystal X-ray diffraction.