Mendeleev Commun. 2014

O.Yu. Bakulina, A.Yu. Ivanov, D.V. Dar’in, P.S. Lobanov

“New transformations of 2-methylsulfanyl-4,6-dichloropyrimidine-5-carbaldehyde involving enamines: synthesis of condensed azines”

Mendeleev Commun 2014, 24, 163-164

DOI: 10.1016/j.mencom.2014.04.013

The reaction between 4,6-dichloropyrimidine-5-carbaldehyde and methyl 3-aminocrotonate leads to pyrido[2,3-d]pyrimidine which reacts with ethyl 3,3-diaminoacrylate to give pyrimido[4,5,6-de][1,6]naphthyridine derivative. The structure of the latter was confirmed by XRD analysis.

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