Archive for 26.06.2014

Делегация Высшей медицинской школы Ганновера

РЦ посетила делегация Высшей медицинской школы Ганновера:

  • Dr. Tilman Fabian, Management Cluster of Excellence “Rebirth”, expert in management of interdisciplinary research projects
  • Prof. Dr. Ullrich Martin, Leibniz Research Laboratory for Biotechnology and Artificial Organs, expert in iPS cells
  • Prof. Dr. Denise Hilfiker-Kleiner, Dean of Research, Hannover Medical School, expert in experimental Cardiology
  • Dr. Robert Zweigerdt, Leibniz Research Laboratory for Biotechnology and Artificial Organs, expert in cell mass production/bioreactors
  • Dr. Andres Hilfiker, Leibniz Research Laboratory for Biotechnology and Artificial Organs, expert in Tissue Engineering
  • Prof. Dr. Axel Schambach, PhD, Department of Hematology, Hannover Medical School, expert in Experimental Hematology
  • Prof. Dr. Alexander Heisterkamp, Leibniz University Hannover, Hannover Laser Center, expert in Biophotonics

Экскурсия 23.06.2014

Сегодня РЦ посетила группа бакалавров с химического факультета.

Chem. Commun. 2014

V.A. Rassadin, E. Nicolas, Y. Six

“Ti(OiPr)4/nBuLi: an attractive reagent system for [2+2+2] cyclotrimerisation reactions”

Chem. Commun. 2014, Advance Article

DOI: 10.1039/C4CC02698E

A convenient method for the [2+2+2] cyclotrimerisation of alkynes using Ti(OiPr)4/nBuLi is presented. Homotrimerisation of arylacetylenes proceeds within minutes with excellent regioselectivity. Moreover, the intermolecular construction of ABB heterotrimers can be achieved selectively from two different alkynes with similar electronic properties. The method is also suitable for the synthesis of pyridines.

Chem. Hetercycl. Compd. 2014

V.V. Sokolov, A.Yu. Ivanov, M.S. Avdontseva, A.A. Zolotarev

“Stereochemistry and NMR Spectra of Some Tricyclic Condensed Thiazolidine Derivatives with a Bridgehead Nitrogen Atom”

Chem. Hetercycl. Compd. 2014, 50, 550-556

DOI: 10.1007/s10593-014-1506-3

The configuration of a series of tricyclic condensed thiazolidines with a bridgehead nitrogen atom, for which erroneous data had been published, was determined by X-ray structural analysis and NMR spectroscopy.

Семинар G-RISC, часть 2

16 и 18 июня прошла вторая часть семинара G-RISC “NMR as interdisciplinary tool for the study of non-covalent interactions”.
Были сделаны следующие доклады:

  • Regina Islamova “Transition Metal-Catalyzed polymerisation: NMR and EPR study”;
  • Roman Yakovenko “NMR study of protonation of carbonyl compounds (fluorinated enones and furanes) in Brønsted superacids”;
  • Konstantin Luzyanin “Combining NMR and MS tools for study of nano clusters in solution”;
  • Kirill Kulish “Zinc(II)-Mediated Generation of 5-amino-1,2,4-oxadiazoles from amidoximes and cyan amides”

Скоро в телевизоре

Аналитические приборы в информационно-аналитической программе.

Tetrahedron Lett. 2014

J. Malinina, T.Q. Tran, A.V. Stepakov, V.V. Gurzhiy, G.L. Starova, R.R. Kostikov, A.P. Molchanov

“[3+2] Cycloaddition reactions of arylallenes with C-(N-arylcarbamoyl)- and C,C-bis(methoxycarbonyl)nitrones and subsequent rearrangements”

Tetrahedron Lett. 2014, 55, 3663-3666

DOI: 10.1016/j.tetlet.2014.04.107


The first example of 1,3-dipolar cycloaddition reactions of nitrones with arylallenes is described. C-Carbamoylnitrones react with the C1single bondC2 double bond of arylallenes affording the corresponding 4-methyleneisoxazolidines in good yields. N-Aryl-C,C-bis(methoxycarbonyl)nitrones usually gave rearranged products: mixtures of 4,5-dihydro-4-oxo-1H-benzo[b]azepine-2,2(3H)dicarboxylates and 4-oxo-1,5-diarylpyrrolidine-2,2-dicarboxylates.

Лекция 17 июня

17 июня в 15:00 в лектории Менделеевского центра состоится лекция профессора Hans-Heinrich Limbach из Dahlem Research School of Molecular Sciences of the Freie Universität Berlin, Germany:

“Functional hydrogen bond NMR: from model systems to nano catalysts and enzymes”

Адрес: СПб, Университетская наб. 7/9, здание НИХИ. Для прохода на территорию университета необходимо предъявить паспорт. Проезд на троллейбусах 1, 7, 10 и автобусах 7, 24, 47, 171. Справки по тел. 323-41-20.

Eur. J. Org. Chem. 2014

P. R. Golubev, A. S. Pankova, M. A. Kuznetsov

“Transition-Metal-Free Approach to 4-Ethynylpyrimidines via Alkenynones”

Eur. J. Org. Chem. 2014, 3614-3621

DOI: 10.1002/ejoc.201402045

A practical approach to the synthesis of 4-ethynylpyrimidines by the condensation of arylamidines with 2-aryl-1-ethoxy-5-(trimethylsilyl)pent-1-en-4-yn-3-ones has been developed. As these latter ketones are easily accessible from bis(trimethylsilyl)acetylene and arylacetyl chlorides, the regioselective condensation reported herein provides a facile access to both TMS-protected and unprotected 4-ethynylpyrimidines in yields of up to 85%.

График работы РЦ в июньские праздники

11 июня – укороченный рабочий день
12-15 июня – выходные дни